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MLL-AF4 B-ALL is highly aggressive and has a very poor overall prognosis which tends to be refractory to conventional anti-leukemia therapies due to the development of resistance and relapse ( MLL-AF4 B-ALL cells by preventing the degradation of MLL-AF4 protein (Liu et al., 2014)
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Peroxidation of arachidonate and other polyunsaturates can occur within membranes, and micelles, and their schism products can initiate cytotoxic chain reactions that alter membrane structure and also attack membrane proteins, and membrane associated DNA
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